电邮这篇文章 Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride
- 作者: Krylov V.I.1, Moiseev S.V.1, Kutin A.A.1, Sakhno N.G.1, Gunar O.V.1, Yashkir V.A.1, Merkulov V.A.1
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隶属关系:
- Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
- 期: 卷 49, 编号 12 (2016)
- 页面: 821-824
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244300
- DOI: https://doi.org/10.1007/s11094-016-1379-0
- ID: 244300
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详细
An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.
作者简介
V. Krylov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051
S. Moiseev
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
编辑信件的主要联系方式.
Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051
A. Kutin
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051
N. Sakhno
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051
O. Gunar
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051
V. Yashkir
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051
V. Merkulov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051
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