Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride


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详细

An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.

作者简介

V. Krylov

Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051

S. Moiseev

Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

编辑信件的主要联系方式.
Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051

A. Kutin

Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051

N. Sakhno

Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051

O. Gunar

Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051

V. Yashkir

Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051

V. Merkulov

Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

Email: MoissevSV@expmed.ru
俄罗斯联邦, Moscow, 127051


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