Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride

V. I. Krylov; S. V. Moiseev; A. A. Kutin; N. G. Sakhno; O. V. Gunar; V. A. Yashkir; V. A. Merkulov

doi:10.1007/s11094-016-1379-0

Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride

Autores: Krylov V.I.¹, Moiseev S.V.¹, Kutin A.A.¹, Sakhno N.G.¹, Gunar O.V.¹, Yashkir V.A.¹, Merkulov V.A.¹
Afiliações:
1. Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Edição: Volume 49, Nº 12 (2016)
Páginas: 821-824
Seção: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244300
DOI: https://doi.org/10.1007/s11094-016-1379-0
ID: 244300

Citar

Texto integral

Acesso aberto
Acesso é fechado

Acesso está concedido
Acesso é fechado

Somente assinantes

Resumo
Sobre autores
Bibliografia
Arquivos suplementares
Estatísticas

Resumo

An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.