Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride
- Autores: Krylov V.1, Moiseev S.1, Kutin A.1, Sakhno N.1, Gunar O.1, Yashkir V.1, Merkulov V.1
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Afiliações:
- Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
- Edição: Volume 49, Nº 12 (2016)
- Páginas: 821-824
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244300
- DOI: https://doi.org/10.1007/s11094-016-1379-0
- ID: 244300
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Resumo
An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.
Sobre autores
V. Krylov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Rússia, Moscow, 127051
S. Moiseev
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Autor responsável pela correspondência
Email: MoissevSV@expmed.ru
Rússia, Moscow, 127051
A. Kutin
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Rússia, Moscow, 127051
N. Sakhno
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Rússia, Moscow, 127051
O. Gunar
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Rússia, Moscow, 127051
V. Yashkir
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Rússia, Moscow, 127051
V. Merkulov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Rússia, Moscow, 127051