Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride
- Авторлар: Krylov V.1, Moiseev S.1, Kutin A.1, Sakhno N.1, Gunar O.1, Yashkir V.1, Merkulov V.1
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Мекемелер:
- Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
- Шығарылым: Том 49, № 12 (2016)
- Беттер: 821-824
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244300
- DOI: https://doi.org/10.1007/s11094-016-1379-0
- ID: 244300
Дәйексөз келтіру
Аннотация
An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.
Авторлар туралы
V. Krylov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Ресей, Moscow, 127051
S. Moiseev
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: MoissevSV@expmed.ru
Ресей, Moscow, 127051
A. Kutin
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Ресей, Moscow, 127051
N. Sakhno
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Ресей, Moscow, 127051
O. Gunar
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Ресей, Moscow, 127051
V. Yashkir
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Ресей, Moscow, 127051
V. Merkulov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Ресей, Moscow, 127051