Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride
- Авторы: Krylov V.1, Moiseev S.1, Kutin A.1, Sakhno N.1, Gunar O.1, Yashkir V.1, Merkulov V.1
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Учреждения:
- Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
- Выпуск: Том 49, № 12 (2016)
- Страницы: 821-824
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244300
- DOI: https://doi.org/10.1007/s11094-016-1379-0
- ID: 244300
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Аннотация
An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.
Об авторах
V. Krylov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Россия, Moscow, 127051
S. Moiseev
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Автор, ответственный за переписку.
Email: MoissevSV@expmed.ru
Россия, Moscow, 127051
A. Kutin
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Россия, Moscow, 127051
N. Sakhno
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Россия, Moscow, 127051
O. Gunar
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Россия, Moscow, 127051
V. Yashkir
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Россия, Moscow, 127051
V. Merkulov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Россия, Moscow, 127051