Synthesis and Pharmacological Activity of 2,9-Disubstituted Imidazo[1,2-a]Benzimidazole Phenyl- and Alkylthiocarbamides
- Авторы: Anisimova V.1, Zhukovskaya O.1, Spasov A.2,3,4, Kuznetsova V.2,3, Kosolapov V.2,3, Yakovlev D.2,4, Solov’eva O.2, Sorotskii D.3, Brigadirova A.2, Vorob’ev E.2
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Учреждения:
- Institute of Physical and Organic Chemistry, Southern Federal University
- Volgograd State Medical University
- Research Institute of Pharmacology, Volgograd State Medical University
- Volgograd Medical Scientific Center, Volgograd State Medical University
- Выпуск: Том 49, № 10 (2016)
- Страницы: 653-656
- Раздел: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244267
- DOI: https://doi.org/10.1007/s11094-016-1346-9
- ID: 244267
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Аннотация
A series of phenyl- and alkylthiocarbamides were synthesized by the reaction of 2,9-disubstituted imidazo-[1,2-a]benzimidazoles with phenyl- and alkylisothiocyanates. The structures of the products were confirmed by elemental analysis and PMR spectroscopy. Some of the synthesized compounds were capable of inhibiting non-enzymatic glycosylation of proteins. The concentration dependences of the antiglycation effect of the most active substances and aminoguanidine were studied.
Об авторах
V. Anisimova
Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Россия, Rostov-on-Don, 344090
O. Zhukovskaya
Institute of Physical and Organic Chemistry, Southern Federal University
Автор, ответственный за переписку.
Email: zhukowskaia.ol@yandex.ru
Россия, Rostov-on-Don, 344090
A. Spasov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University; Volgograd Medical Scientific Center, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd, 400131; Volgograd, 400131; Volgograd, 400131
V. Kuznetsova
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd, 400131; Volgograd, 400131
V. Kosolapov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd, 400131; Volgograd, 400131
D. Yakovlev
Volgograd State Medical University; Volgograd Medical Scientific Center, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd, 400131; Volgograd, 400131
O. Solov’eva
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd, 400131
D. Sorotskii
Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd, 400131
A. Brigadirova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd, 400131
E. Vorob’ev
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd, 400131