Email this article Synthesis and Pharmacological Activity of 2,9-Disubstituted Imidazo[1,2-a]Benzimidazole Phenyl- and Alkylthiocarbamides
- Authors: Anisimova V.A.1, Zhukovskaya O.N.1, Spasov A.A.2,3,4, Kuznetsova V.A.2,3, Kosolapov V.A.2,3, Yakovlev D.S.2,4, Solov’eva O.A.2, Sorotskii D.V.3, Brigadirova A.A.2, Vorob’ev E.S.2
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Affiliations:
- Institute of Physical and Organic Chemistry, Southern Federal University
- Volgograd State Medical University
- Research Institute of Pharmacology, Volgograd State Medical University
- Volgograd Medical Scientific Center, Volgograd State Medical University
- Issue: Vol 49, No 10 (2016)
- Pages: 653-656
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244267
- DOI: https://doi.org/10.1007/s11094-016-1346-9
- ID: 244267
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Abstract
A series of phenyl- and alkylthiocarbamides were synthesized by the reaction of 2,9-disubstituted imidazo-[1,2-a]benzimidazoles with phenyl- and alkylisothiocyanates. The structures of the products were confirmed by elemental analysis and PMR spectroscopy. Some of the synthesized compounds were capable of inhibiting non-enzymatic glycosylation of proteins. The concentration dependences of the antiglycation effect of the most active substances and aminoguanidine were studied.
About the authors
V. A. Anisimova
Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Rostov-on-Don, 344090
O. N. Zhukovskaya
Institute of Physical and Organic Chemistry, Southern Federal University
Author for correspondence.
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Rostov-on-Don, 344090
A. A. Spasov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University; Volgograd Medical Scientific Center, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131; Volgograd, 400131
V. A. Kuznetsova
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
V. A. Kosolapov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
D. S. Yakovlev
Volgograd State Medical University; Volgograd Medical Scientific Center, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
O. A. Solov’eva
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
D. V. Sorotskii
Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
A. A. Brigadirova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
E. S. Vorob’ev
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
