Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)- 5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives
- Autores: Gein V.1, Kasimova N.1, Chashchina S.1, Starkova A.1, Syropyatov B.1
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Afiliações:
- Perm State Pharmaceutical Academy, Ministry of Health of the RF
- Edição: Volume 53, Nº 8 (2019)
- Páginas: 701-705
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245954
- DOI: https://doi.org/10.1007/s11094-019-02066-0
- ID: 245954
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Resumo
A series of 1-(2-aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by three-component reactions of 4-substituted 2,4-dioxobutanoic acid methyl esters with mixtures of an aromatic aldehyde and 1,2-diaminopropane. Products of their reactions with hydrazine, p-phenetidine, and acetic anhydride were obtained. The analgesic, anti-inflammatory, and antimicrobial activities and hemostatic effect of several compounds were studied.
Sobre autores
V. Gein
Perm State Pharmaceutical Academy, Ministry of Health of the RF
Email: nata-kashome@yandex.ru
Rússia, 2 Polevaya St, Perm, 614990
N. Kasimova
Perm State Pharmaceutical Academy, Ministry of Health of the RF
Autor responsável pela correspondência
Email: nata-kashome@yandex.ru
Rússia, 2 Polevaya St, Perm, 614990
S. Chashchina
Perm State Pharmaceutical Academy, Ministry of Health of the RF
Email: nata-kashome@yandex.ru
Rússia, 2 Polevaya St, Perm, 614990
A. Starkova
Perm State Pharmaceutical Academy, Ministry of Health of the RF
Email: nata-kashome@yandex.ru
Rússia, 2 Polevaya St, Perm, 614990
B. Syropyatov
Perm State Pharmaceutical Academy, Ministry of Health of the RF
Email: nata-kashome@yandex.ru
Rússia, 2 Polevaya St, Perm, 614990