Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)- 5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives

V. L. Gein; N. N. Kasimova; S. V. Chashchina; A. V. Starkova; B. Ya. Syropyatov

doi:10.1007/s11094-019-02066-0

Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)- 5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives

Authors: Gein V.L.¹, Kasimova N.N.¹, Chashchina S.V.¹, Starkova A.V.¹, Syropyatov B.Y.¹
Affiliations:
1. Perm State Pharmaceutical Academy, Ministry of Health of the RF
Issue: Vol 53, No 8 (2019)
Pages: 701-705
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/245954
DOI: https://doi.org/10.1007/s11094-019-02066-0
ID: 245954

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Abstract

A series of 1-(2-aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by three-component reactions of 4-substituted 2,4-dioxobutanoic acid methyl esters with mixtures of an aromatic aldehyde and 1,2-diaminopropane. Products of their reactions with hydrazine, p-phenetidine, and acetic anhydride were obtained. The analgesic, anti-inflammatory, and antimicrobial activities and hemostatic effect of several compounds were studied.