Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)- 5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives
- Авторы: Gein V.1, Kasimova N.1, Chashchina S.1, Starkova A.1, Syropyatov B.1
-
Учреждения:
- Perm State Pharmaceutical Academy, Ministry of Health of the RF
- Выпуск: Том 53, № 8 (2019)
- Страницы: 701-705
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245954
- DOI: https://doi.org/10.1007/s11094-019-02066-0
- ID: 245954
Цитировать
Аннотация
A series of 1-(2-aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by three-component reactions of 4-substituted 2,4-dioxobutanoic acid methyl esters with mixtures of an aromatic aldehyde and 1,2-diaminopropane. Products of their reactions with hydrazine, p-phenetidine, and acetic anhydride were obtained. The analgesic, anti-inflammatory, and antimicrobial activities and hemostatic effect of several compounds were studied.
Об авторах
V. Gein
Perm State Pharmaceutical Academy, Ministry of Health of the RF
Email: nata-kashome@yandex.ru
Россия, 2 Polevaya St, Perm, 614990
N. Kasimova
Perm State Pharmaceutical Academy, Ministry of Health of the RF
Автор, ответственный за переписку.
Email: nata-kashome@yandex.ru
Россия, 2 Polevaya St, Perm, 614990
S. Chashchina
Perm State Pharmaceutical Academy, Ministry of Health of the RF
Email: nata-kashome@yandex.ru
Россия, 2 Polevaya St, Perm, 614990
A. Starkova
Perm State Pharmaceutical Academy, Ministry of Health of the RF
Email: nata-kashome@yandex.ru
Россия, 2 Polevaya St, Perm, 614990
B. Syropyatov
Perm State Pharmaceutical Academy, Ministry of Health of the RF
Email: nata-kashome@yandex.ru
Россия, 2 Polevaya St, Perm, 614990