Enviar artigo por via de e-mail Bioequivalence of a Dosage form of the New Drug Mefebut
- Autores: Smirnova L.1,2, Suchkov E.1,2, Ryabukha A.1,2, Kuznetsov K.1,2, Velikopol’skaya M.1, Tyurenkov I.1, Bakulin D.1, Stepanova É.3, Shevchenko A.3
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Afiliações:
- Volgograd State Medical University
- Volgograd Medical Scientific Center
- Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
- Edição: Volume 52, Nº 6 (2018)
- Páginas: 495-496
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245274
- DOI: https://doi.org/10.1007/s11094-018-1846-x
- ID: 245274
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Resumo
The bioequivalence of mefebut drug substance and its tablet dosage form was investigated by studying the main pharmacokinetic parameters and calculating the relative bioavailability. The results showed that mefebut circulated for up to 4 h in rabbit blood after peroral administration. The relative bioavailability was 97.4%.
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Sobre autores
L. Smirnova
Volgograd State Medical University; Volgograd Medical Scientific Center
Autor responsável pela correspondência
Email: post@volgmed.ru
Rússia, 1 Pavshikh Bortsov Sq, Volgograd, 400131; 1 Pavshikh Bortsov Sq, Volgograd, 400131
E. Suchkov
Volgograd State Medical University; Volgograd Medical Scientific Center
Email: post@volgmed.ru
Rússia, 1 Pavshikh Bortsov Sq, Volgograd, 400131; 1 Pavshikh Bortsov Sq, Volgograd, 400131
A. Ryabukha
Volgograd State Medical University; Volgograd Medical Scientific Center
Email: post@volgmed.ru
Rússia, 1 Pavshikh Bortsov Sq, Volgograd, 400131; 1 Pavshikh Bortsov Sq, Volgograd, 400131
K. Kuznetsov
Volgograd State Medical University; Volgograd Medical Scientific Center
Email: post@volgmed.ru
Rússia, 1 Pavshikh Bortsov Sq, Volgograd, 400131; 1 Pavshikh Bortsov Sq, Volgograd, 400131
M. Velikopol’skaya
Volgograd State Medical University
Email: post@volgmed.ru
Rússia, 1 Pavshikh Bortsov Sq, Volgograd, 400131
I. Tyurenkov
Volgograd State Medical University
Email: post@volgmed.ru
Rússia, 1 Pavshikh Bortsov Sq, Volgograd, 400131
D. Bakulin
Volgograd State Medical University
Email: post@volgmed.ru
Rússia, 1 Pavshikh Bortsov Sq, Volgograd, 400131
É. Stepanova
Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
Email: post@volgmed.ru
Rússia, 11 Prosp. Kalinina, Pyatigorsk, 357532
A. Shevchenko
Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
Email: post@volgmed.ru
Rússia, 11 Prosp. Kalinina, Pyatigorsk, 357532
