Email this article Bioequivalence of a Dosage form of the New Drug Mefebut
- Authors: Smirnova L.A.1,2, Suchkov E.A.1,2, Ryabukha A.F.1,2, Kuznetsov K.A.1,2, Velikopol’skaya M.V.1, Tyurenkov I.N.1, Bakulin D.A.1, Stepanova É.F.3, Shevchenko A.M.3
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Affiliations:
- Volgograd State Medical University
- Volgograd Medical Scientific Center
- Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
- Issue: Vol 52, No 6 (2018)
- Pages: 495-496
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245274
- DOI: https://doi.org/10.1007/s11094-018-1846-x
- ID: 245274
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Abstract
The bioequivalence of mefebut drug substance and its tablet dosage form was investigated by studying the main pharmacokinetic parameters and calculating the relative bioavailability. The results showed that mefebut circulated for up to 4 h in rabbit blood after peroral administration. The relative bioavailability was 97.4%.
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About the authors
L. A. Smirnova
Volgograd State Medical University; Volgograd Medical Scientific Center
Author for correspondence.
Email: post@volgmed.ru
Russian Federation, 1 Pavshikh Bortsov Sq, Volgograd, 400131; 1 Pavshikh Bortsov Sq, Volgograd, 400131
E. A. Suchkov
Volgograd State Medical University; Volgograd Medical Scientific Center
Email: post@volgmed.ru
Russian Federation, 1 Pavshikh Bortsov Sq, Volgograd, 400131; 1 Pavshikh Bortsov Sq, Volgograd, 400131
A. F. Ryabukha
Volgograd State Medical University; Volgograd Medical Scientific Center
Email: post@volgmed.ru
Russian Federation, 1 Pavshikh Bortsov Sq, Volgograd, 400131; 1 Pavshikh Bortsov Sq, Volgograd, 400131
K. A. Kuznetsov
Volgograd State Medical University; Volgograd Medical Scientific Center
Email: post@volgmed.ru
Russian Federation, 1 Pavshikh Bortsov Sq, Volgograd, 400131; 1 Pavshikh Bortsov Sq, Volgograd, 400131
M. V. Velikopol’skaya
Volgograd State Medical University
Email: post@volgmed.ru
Russian Federation, 1 Pavshikh Bortsov Sq, Volgograd, 400131
I. N. Tyurenkov
Volgograd State Medical University
Email: post@volgmed.ru
Russian Federation, 1 Pavshikh Bortsov Sq, Volgograd, 400131
D. A. Bakulin
Volgograd State Medical University
Email: post@volgmed.ru
Russian Federation, 1 Pavshikh Bortsov Sq, Volgograd, 400131
É. F. Stepanova
Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
Email: post@volgmed.ru
Russian Federation, 11 Prosp. Kalinina, Pyatigorsk, 357532
A. M. Shevchenko
Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
Email: post@volgmed.ru
Russian Federation, 11 Prosp. Kalinina, Pyatigorsk, 357532
