Synthesis and Biological Activity of 4-ARYL-2-[(2-OXO-1,2-Diphenylethylidene)-Hydrazinyl]-4-Oxobut-2-Enoic-Acid Amides
- Autores: Bykov R.1, Trapeznikova N.2, Balandina S.1, Komarova O.1, Makhmudov R.1, Pulina N.3, Sobin F.1, Rubtsov A.1
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Afiliações:
- Perm State National Research University
- D. N. Pryanishnikov Perm State Agricultural Academy
- Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
- Edição: Volume 52, Nº 5 (2018)
- Páginas: 415-418
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245223
- DOI: https://doi.org/10.1007/s11094-018-1833-2
- ID: 245223
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Resumo
4-Aryl-2-[(2-oxo-1,2-diphenylethylidene)hydrazinyl]-4-oxobut-2-enoic-acid amides were produced via decyclization of 3-[(2-oxo-1,2-diphenylethylidene)hydrazono]-5-arylfuran-2(3H)-ones by the corresponding amines and via reaction of 4-aryl-2-hydroxy-4-oxobut-2-enoic-acid hetarylamides with 2-hydrazono-1,2-diphenylethanone. Their analgesic and antibacterial activities were studied. Compounds with low toxicities and activities comparable to and exceeding those of reference drugs were discovered.
Sobre autores
R. Bykov
Perm State National Research University
Email: rubtsov@psu.ru
Rússia, 15 Bukireva, Perm, 614036
N. Trapeznikova
D. N. Pryanishnikov Perm State Agricultural Academy
Email: rubtsov@psu.ru
Rússia, 53 Petropavlovskaya, Perm, 614990
S. Balandina
Perm State National Research University
Email: rubtsov@psu.ru
Rússia, 15 Bukireva, Perm, 614036
O. Komarova
Perm State National Research University
Email: rubtsov@psu.ru
Rússia, 15 Bukireva, Perm, 614036
R. Makhmudov
Perm State National Research University
Email: rubtsov@psu.ru
Rússia, 15 Bukireva, Perm, 614036
N. Pulina
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: rubtsov@psu.ru
Rússia, 46 Krupskoi, Perm, 614000
F. Sobin
Perm State National Research University
Email: rubtsov@psu.ru
Rússia, 15 Bukireva, Perm, 614036
A. Rubtsov
Perm State National Research University
Autor responsável pela correspondência
Email: rubtsov@psu.ru
Rússia, 15 Bukireva, Perm, 614036