Synthesis and Biological Activity of 4-ARYL-2-[(2-OXO-1,2-Diphenylethylidene)-Hydrazinyl]-4-Oxobut-2-Enoic-Acid Amides
- Авторы: Bykov R.1, Trapeznikova N.2, Balandina S.1, Komarova O.1, Makhmudov R.1, Pulina N.3, Sobin F.1, Rubtsov A.1
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Учреждения:
- Perm State National Research University
- D. N. Pryanishnikov Perm State Agricultural Academy
- Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
- Выпуск: Том 52, № 5 (2018)
- Страницы: 415-418
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245223
- DOI: https://doi.org/10.1007/s11094-018-1833-2
- ID: 245223
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Аннотация
4-Aryl-2-[(2-oxo-1,2-diphenylethylidene)hydrazinyl]-4-oxobut-2-enoic-acid amides were produced via decyclization of 3-[(2-oxo-1,2-diphenylethylidene)hydrazono]-5-arylfuran-2(3H)-ones by the corresponding amines and via reaction of 4-aryl-2-hydroxy-4-oxobut-2-enoic-acid hetarylamides with 2-hydrazono-1,2-diphenylethanone. Their analgesic and antibacterial activities were studied. Compounds with low toxicities and activities comparable to and exceeding those of reference drugs were discovered.
Об авторах
R. Bykov
Perm State National Research University
Email: rubtsov@psu.ru
Россия, 15 Bukireva, Perm, 614036
N. Trapeznikova
D. N. Pryanishnikov Perm State Agricultural Academy
Email: rubtsov@psu.ru
Россия, 53 Petropavlovskaya, Perm, 614990
S. Balandina
Perm State National Research University
Email: rubtsov@psu.ru
Россия, 15 Bukireva, Perm, 614036
O. Komarova
Perm State National Research University
Email: rubtsov@psu.ru
Россия, 15 Bukireva, Perm, 614036
R. Makhmudov
Perm State National Research University
Email: rubtsov@psu.ru
Россия, 15 Bukireva, Perm, 614036
N. Pulina
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: rubtsov@psu.ru
Россия, 46 Krupskoi, Perm, 614000
F. Sobin
Perm State National Research University
Email: rubtsov@psu.ru
Россия, 15 Bukireva, Perm, 614036
A. Rubtsov
Perm State National Research University
Автор, ответственный за переписку.
Email: rubtsov@psu.ru
Россия, 15 Bukireva, Perm, 614036