Synthesis and Biological Activity of 4-ARYL-2-[(2-OXO-1,2-Diphenylethylidene)-Hydrazinyl]-4-Oxobut-2-Enoic-Acid Amides
- Authors: Bykov R.A.1, Trapeznikova N.N.2, Balandina S.Y.1, Komarova O.A.1, Makhmudov R.R.1, Pulina N.A.3, Sobin F.V.1, Rubtsov A.E.1
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Affiliations:
- Perm State National Research University
- D. N. Pryanishnikov Perm State Agricultural Academy
- Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
- Issue: Vol 52, No 5 (2018)
- Pages: 415-418
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245223
- DOI: https://doi.org/10.1007/s11094-018-1833-2
- ID: 245223
Cite item
Abstract
4-Aryl-2-[(2-oxo-1,2-diphenylethylidene)hydrazinyl]-4-oxobut-2-enoic-acid amides were produced via decyclization of 3-[(2-oxo-1,2-diphenylethylidene)hydrazono]-5-arylfuran-2(3H)-ones by the corresponding amines and via reaction of 4-aryl-2-hydroxy-4-oxobut-2-enoic-acid hetarylamides with 2-hydrazono-1,2-diphenylethanone. Their analgesic and antibacterial activities were studied. Compounds with low toxicities and activities comparable to and exceeding those of reference drugs were discovered.
About the authors
R. A. Bykov
Perm State National Research University
Email: rubtsov@psu.ru
Russian Federation, 15 Bukireva, Perm, 614036
N. N. Trapeznikova
D. N. Pryanishnikov Perm State Agricultural Academy
Email: rubtsov@psu.ru
Russian Federation, 53 Petropavlovskaya, Perm, 614990
S. Yu. Balandina
Perm State National Research University
Email: rubtsov@psu.ru
Russian Federation, 15 Bukireva, Perm, 614036
O. A. Komarova
Perm State National Research University
Email: rubtsov@psu.ru
Russian Federation, 15 Bukireva, Perm, 614036
R. R. Makhmudov
Perm State National Research University
Email: rubtsov@psu.ru
Russian Federation, 15 Bukireva, Perm, 614036
N. A. Pulina
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: rubtsov@psu.ru
Russian Federation, 46 Krupskoi, Perm, 614000
F. V. Sobin
Perm State National Research University
Email: rubtsov@psu.ru
Russian Federation, 15 Bukireva, Perm, 614036
A. E. Rubtsov
Perm State National Research University
Author for correspondence.
Email: rubtsov@psu.ru
Russian Federation, 15 Bukireva, Perm, 614036