Synthesis and Biological Activity of 4-ARYL-2-[(2-OXO-1,2-Diphenylethylidene)-Hydrazinyl]-4-Oxobut-2-Enoic-Acid Amides

R. A. Bykov; N. N. Trapeznikova; S. Yu. Balandina; O. A. Komarova; R. R. Makhmudov; N. A. Pulina; F. V. Sobin; A. E. Rubtsov

doi:10.1007/s11094-018-1833-2

Synthesis and Biological Activity of 4-ARYL-2-[(2-OXO-1,2-Diphenylethylidene)-Hydrazinyl]-4-Oxobut-2-Enoic-Acid Amides

Authors: Bykov R.A.¹, Trapeznikova N.N.², Balandina S.Y.¹, Komarova O.A.¹, Makhmudov R.R.¹, Pulina N.A.³, Sobin F.V.¹, Rubtsov A.E.¹
Affiliations:
1. Perm State National Research University
2. D. N. Pryanishnikov Perm State Agricultural Academy
3. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Issue: Vol 52, No 5 (2018)
Pages: 415-418
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/245223
DOI: https://doi.org/10.1007/s11094-018-1833-2
ID: 245223

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Abstract

4-Aryl-2-[(2-oxo-1,2-diphenylethylidene)hydrazinyl]-4-oxobut-2-enoic-acid amides were produced via decyclization of 3-[(2-oxo-1,2-diphenylethylidene)hydrazono]-5-arylfuran-2(3H)-ones by the corresponding amines and via reaction of 4-aryl-2-hydroxy-4-oxobut-2-enoic-acid hetarylamides with 2-hydrazono-1,2-diphenylethanone. Their analgesic and antibacterial activities were studied. Compounds with low toxicities and activities comparable to and exceeding those of reference drugs were discovered.