Synthesis, Antimicrobial and In Silico EGFR Inhibitory Activity Evaluation of Sulfonylamino Pyrrolidine Derivatives
- Autores: Kumar B.1, Prasad A.2, Reddy P.1, Ravindranath L.1
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Afiliações:
- Sri Krishnadevaraya University
- Faculty of Science and Technology, ICFAI Foundation for Higher Education
- Edição: Volume 50, Nº 7 (2016)
- Páginas: 443-450
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244414
- DOI: https://doi.org/10.1007/s11094-016-1467-1
- ID: 244414
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Resumo
A series of novel sulfonylamino pyrrolidine derivatives were synthesized, characterized and evaluated for their antimicrobial activity. All compounds exhibited moderate activity against the microorganisms tested. The compounds were evaluated in silico for their ability to inhibit epidermal growth factor receptor (EGFR). Docking in silico demonstrated that the sulfonylamino pyrrolidine derivatives represent a new class of EGFR inhibitors and bind at the ATP binding pocket of the tyrosine kinase domain of EGFR. The free energy of binding and inhibition constant (ki) of the docked compounds were evaluated.
Sobre autores
B. Kumar
Sri Krishnadevaraya University
Email: guruprasadar@yahoo.co.in
Índia, Anantapur, A. P.
A. Prasad
Faculty of Science and Technology, ICFAI Foundation for Higher Education
Autor responsável pela correspondência
Email: guruprasadar@yahoo.co.in
Índia, Hyderabad, Telangana
P. Reddy
Sri Krishnadevaraya University
Email: guruprasadar@yahoo.co.in
Índia, Anantapur, A. P.
L. Ravindranath
Sri Krishnadevaraya University
Email: guruprasadar@yahoo.co.in
Índia, Anantapur, A. P.