Synthesis, Antimicrobial and In Silico EGFR Inhibitory Activity Evaluation of Sulfonylamino Pyrrolidine Derivatives
- Авторы: Kumar B.1, Prasad A.2, Reddy P.1, Ravindranath L.1
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Учреждения:
- Sri Krishnadevaraya University
- Faculty of Science and Technology, ICFAI Foundation for Higher Education
- Выпуск: Том 50, № 7 (2016)
- Страницы: 443-450
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244414
- DOI: https://doi.org/10.1007/s11094-016-1467-1
- ID: 244414
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Аннотация
A series of novel sulfonylamino pyrrolidine derivatives were synthesized, characterized and evaluated for their antimicrobial activity. All compounds exhibited moderate activity against the microorganisms tested. The compounds were evaluated in silico for their ability to inhibit epidermal growth factor receptor (EGFR). Docking in silico demonstrated that the sulfonylamino pyrrolidine derivatives represent a new class of EGFR inhibitors and bind at the ATP binding pocket of the tyrosine kinase domain of EGFR. The free energy of binding and inhibition constant (ki) of the docked compounds were evaluated.
Об авторах
B. Kumar
Sri Krishnadevaraya University
Email: guruprasadar@yahoo.co.in
Индия, Anantapur, A. P.
A. Prasad
Faculty of Science and Technology, ICFAI Foundation for Higher Education
Автор, ответственный за переписку.
Email: guruprasadar@yahoo.co.in
Индия, Hyderabad, Telangana
P. Reddy
Sri Krishnadevaraya University
Email: guruprasadar@yahoo.co.in
Индия, Anantapur, A. P.
L. Ravindranath
Sri Krishnadevaraya University
Email: guruprasadar@yahoo.co.in
Индия, Anantapur, A. P.