Synthesis and Cytotoxic Activity of Arylsubstituted Tetrazolocyclanopyrimidines

N. O. Vasil’kova; M. A. Ivonin; G. L. Burygin; A. Yu. Prilepskii; A. P. Kriven’ko

doi:10.1007/s11094-017-1687-z

Synthesis and Cytotoxic Activity of Arylsubstituted Tetrazolocyclanopyrimidines

Авторлар: Vasil’kova N.¹, Ivonin M.¹, Burygin G.², Prilepskii A.², Kriven’ko A.¹
Мекемелер:
1. N. G. Chernyshevskii Saratov State National Research University
2. Institute of Plant and Microbial Biochemistry and Physiology
Шығарылым: Том 51, № 9 (2017)
Беттер: 756-759
Бөлім: The Search for New Drugs
URL: https://journals.rcsi.science/0091-150X/article/view/244789
DOI: https://doi.org/10.1007/s11094-017-1687-z
ID: 244789

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Аннотация

A series of arylsubstituted tetrazolocyclanodihydropyrimidines was prepared and their cytotoxic actions on SPEV-2 cells were studied. The activity of these substances was found to depend on the nature and position of the substitution groups in the benzene ring and the size of the alicycle. The most active compounds were o-chloro(methyl)phenyltetrazolohexahydroquinazolines.