Synthesis and Cytotoxic Activity of Arylsubstituted Tetrazolocyclanopyrimidines

N. O. Vasil’kova; M. A. Ivonin; G. L. Burygin; A. Yu. Prilepskii; A. P. Kriven’ko

doi:10.1007/s11094-017-1687-z

Synthesis and Cytotoxic Activity of Arylsubstituted Tetrazolocyclanopyrimidines

Authors: Vasil’kova N.O.¹, Ivonin M.A.¹, Burygin G.L.², Prilepskii A.Y.², Kriven’ko A.P.¹
Affiliations:
1. N. G. Chernyshevskii Saratov State National Research University
2. Institute of Plant and Microbial Biochemistry and Physiology
Issue: Vol 51, No 9 (2017)
Pages: 756-759
Section: The Search for New Drugs
URL: https://journals.rcsi.science/0091-150X/article/view/244789
DOI: https://doi.org/10.1007/s11094-017-1687-z
ID: 244789

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Abstract

A series of arylsubstituted tetrazolocyclanodihydropyrimidines was prepared and their cytotoxic actions on SPEV-2 cells were studied. The activity of these substances was found to depend on the nature and position of the substitution groups in the benzene ring and the size of the alicycle. The most active compounds were o-chloro(methyl)phenyltetrazolohexahydroquinazolines.