Synthesis and Biological Properties of {[(4-Hydroxy-1-Methyl-2,2-Dioxido-1H-2,1-Benzothiazin-3-YL)Carbonyl]Amino}-Benzoic Acids and Their Derivatives
- Авторлар: Ukrainets I.1, Petrushova L.2, Dzyubenko S.3, Grinevich L.1, Sim G.3
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Мекемелер:
- National Pharmaceutical University
- Vinnitsa N. I. Pirogov National Medical University
- Far East State Medical University
- Шығарылым: Том 51, № 7 (2017)
- Беттер: 553-557
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244705
- DOI: https://doi.org/10.1007/s11094-017-1653-9
- ID: 244705
Дәйексөз келтіру
Аннотация
Continuing the search for novel biologically active substances among the 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides series, we report here the synthesis of a series of {[(4-hydroxy-1-methyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)carbonyl]amino} benzoic acids asd their derivatives at the carboxyl group. Pharmacological testing showed that compounds with a free carboxyl group are of interest as potential diuretics, while carbamide derivatives have potential as analgesics. Esterification of the carboxyl group with lower alkyl alcohols was less effective.
Негізгі сөздер
Авторлар туралы
I. Ukrainets
National Pharmaceutical University
Email: chem@folium.ru
Украина, Kharkov
L. Petrushova
Vinnitsa N. I. Pirogov National Medical University
Email: chem@folium.ru
Украина, Vinnitsa
S. Dzyubenko
Far East State Medical University
Email: chem@folium.ru
Ресей, Khabarovsk
L. Grinevich
National Pharmaceutical University
Email: chem@folium.ru
Украина, Kharkov
G. Sim
Far East State Medical University
Email: chem@folium.ru
Ресей, Khabarovsk