Synthesis and Biological Properties of {[(4-Hydroxy-1-Methyl-2,2-Dioxido-1H-2,1-Benzothiazin-3-YL)Carbonyl]Amino}-Benzoic Acids and Their Derivatives
- Authors: Ukrainets I.V.1, Petrushova L.A.2, Dzyubenko S.P.3, Grinevich L.A.1, Sim G.3
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Affiliations:
- National Pharmaceutical University
- Vinnitsa N. I. Pirogov National Medical University
- Far East State Medical University
- Issue: Vol 51, No 7 (2017)
- Pages: 553-557
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244705
- DOI: https://doi.org/10.1007/s11094-017-1653-9
- ID: 244705
Cite item
Abstract
Continuing the search for novel biologically active substances among the 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides series, we report here the synthesis of a series of {[(4-hydroxy-1-methyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)carbonyl]amino} benzoic acids asd their derivatives at the carboxyl group. Pharmacological testing showed that compounds with a free carboxyl group are of interest as potential diuretics, while carbamide derivatives have potential as analgesics. Esterification of the carboxyl group with lower alkyl alcohols was less effective.
About the authors
I. V. Ukrainets
National Pharmaceutical University
Email: chem@folium.ru
Ukraine, Kharkov
L. A. Petrushova
Vinnitsa N. I. Pirogov National Medical University
Email: chem@folium.ru
Ukraine, Vinnitsa
S. P. Dzyubenko
Far East State Medical University
Email: chem@folium.ru
Russian Federation, Khabarovsk
L. A. Grinevich
National Pharmaceutical University
Email: chem@folium.ru
Ukraine, Kharkov
G. Sim
Far East State Medical University
Email: chem@folium.ru
Russian Federation, Khabarovsk