Synthesis and Biological Properties of {[(4-Hydroxy-1-Methyl-2,2-Dioxido-1H-2,1-Benzothiazin-3-YL)Carbonyl]Amino}-Benzoic Acids and Their Derivatives
- Autores: Ukrainets I.1, Petrushova L.2, Dzyubenko S.3, Grinevich L.1, Sim G.3
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Afiliações:
- National Pharmaceutical University
- Vinnitsa N. I. Pirogov National Medical University
- Far East State Medical University
- Edição: Volume 51, Nº 7 (2017)
- Páginas: 553-557
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244705
- DOI: https://doi.org/10.1007/s11094-017-1653-9
- ID: 244705
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Resumo
Continuing the search for novel biologically active substances among the 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides series, we report here the synthesis of a series of {[(4-hydroxy-1-methyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)carbonyl]amino} benzoic acids asd their derivatives at the carboxyl group. Pharmacological testing showed that compounds with a free carboxyl group are of interest as potential diuretics, while carbamide derivatives have potential as analgesics. Esterification of the carboxyl group with lower alkyl alcohols was less effective.
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Sobre autores
I. Ukrainets
National Pharmaceutical University
Email: chem@folium.ru
Ucrânia, Kharkov
L. Petrushova
Vinnitsa N. I. Pirogov National Medical University
Email: chem@folium.ru
Ucrânia, Vinnitsa
S. Dzyubenko
Far East State Medical University
Email: chem@folium.ru
Rússia, Khabarovsk
L. Grinevich
National Pharmaceutical University
Email: chem@folium.ru
Ucrânia, Kharkov
G. Sim
Far East State Medical University
Email: chem@folium.ru
Rússia, Khabarovsk