Synthesis of Pyrimidino Derivatives: Potent Antimicrobial Candidates
- Авторлар: Chauhan R.1, Siddiqi A.2, Dwivedi J.3
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Мекемелер:
- Department of Pharmacy, Banasthali University
- Department of Pharmacy, Jamia Hamdard University
- Department of Chemistry, Banasthali University
- Шығарылым: Том 50, № 10 (2017)
- Беттер: 678-683
- Бөлім: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/244458
- DOI: https://doi.org/10.1007/s11094-017-1511-9
- ID: 244458
Дәйексөз келтіру
Аннотация
A series of pyimidino derivatives including 4,5-dihydro-5-(1H-indol-1-yl)-6-(phenyl)-4-(4-substituted phenyl) pyrimidine-2-(1H)-one/thione and 4,5-dihydro-4-(3,4,5-trimethoxyphenyl)-6-phenyl-5-[3-(substitute-1-yl))-1H-indol-1-yl]pyrimidin-2(1H)-one/thione have been synthesis and their antimicrobial activity has been assessed in order to study the antimicrobial synergism of indole and benzene nuclei in single molecule. The structures of synthesized compounds were confirmed by IR, NMR and mass spectroscopy data. Antimicrobial activity assessment gives comparable to excellent results against all test microbes. It is concluded that nuclei separately possessing antimicrobial activity exhibit synergism when combined in a single molecule.
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Авторлар туралы
R. Chauhan
Department of Pharmacy, Banasthali University
Хат алмасуға жауапты Автор.
Email: rajanichauhan.pharma@yahoo.com
Үндістан, Tonk, Rajasthan, 304022
A. Siddiqi
Department of Pharmacy, Jamia Hamdard University
Email: rajanichauhan.pharma@yahoo.com
Үндістан, New Delhi
J. Dwivedi
Department of Chemistry, Banasthali University
Email: rajanichauhan.pharma@yahoo.com
Үндістан, Tonk, Rajasthan, 304022