Synthesis of Pyrimidino Derivatives: Potent Antimicrobial Candidates
- 作者: Chauhan R.1, Siddiqi A.2, Dwivedi J.3
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隶属关系:
- Department of Pharmacy, Banasthali University
- Department of Pharmacy, Jamia Hamdard University
- Department of Chemistry, Banasthali University
- 期: 卷 50, 编号 10 (2017)
- 页面: 678-683
- 栏目: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/244458
- DOI: https://doi.org/10.1007/s11094-017-1511-9
- ID: 244458
如何引用文章
详细
A series of pyimidino derivatives including 4,5-dihydro-5-(1H-indol-1-yl)-6-(phenyl)-4-(4-substituted phenyl) pyrimidine-2-(1H)-one/thione and 4,5-dihydro-4-(3,4,5-trimethoxyphenyl)-6-phenyl-5-[3-(substitute-1-yl))-1H-indol-1-yl]pyrimidin-2(1H)-one/thione have been synthesis and their antimicrobial activity has been assessed in order to study the antimicrobial synergism of indole and benzene nuclei in single molecule. The structures of synthesized compounds were confirmed by IR, NMR and mass spectroscopy data. Antimicrobial activity assessment gives comparable to excellent results against all test microbes. It is concluded that nuclei separately possessing antimicrobial activity exhibit synergism when combined in a single molecule.
作者简介
R. Chauhan
Department of Pharmacy, Banasthali University
编辑信件的主要联系方式.
Email: rajanichauhan.pharma@yahoo.com
印度, Tonk, Rajasthan, 304022
A. Siddiqi
Department of Pharmacy, Jamia Hamdard University
Email: rajanichauhan.pharma@yahoo.com
印度, New Delhi
J. Dwivedi
Department of Chemistry, Banasthali University
Email: rajanichauhan.pharma@yahoo.com
印度, Tonk, Rajasthan, 304022