Synthesis of Pyrimidino Derivatives: Potent Antimicrobial Candidates
- Авторы: Chauhan R.1, Siddiqi A.2, Dwivedi J.3
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Учреждения:
- Department of Pharmacy, Banasthali University
- Department of Pharmacy, Jamia Hamdard University
- Department of Chemistry, Banasthali University
- Выпуск: Том 50, № 10 (2017)
- Страницы: 678-683
- Раздел: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/244458
- DOI: https://doi.org/10.1007/s11094-017-1511-9
- ID: 244458
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Аннотация
A series of pyimidino derivatives including 4,5-dihydro-5-(1H-indol-1-yl)-6-(phenyl)-4-(4-substituted phenyl) pyrimidine-2-(1H)-one/thione and 4,5-dihydro-4-(3,4,5-trimethoxyphenyl)-6-phenyl-5-[3-(substitute-1-yl))-1H-indol-1-yl]pyrimidin-2(1H)-one/thione have been synthesis and their antimicrobial activity has been assessed in order to study the antimicrobial synergism of indole and benzene nuclei in single molecule. The structures of synthesized compounds were confirmed by IR, NMR and mass spectroscopy data. Antimicrobial activity assessment gives comparable to excellent results against all test microbes. It is concluded that nuclei separately possessing antimicrobial activity exhibit synergism when combined in a single molecule.
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Об авторах
R. Chauhan
Department of Pharmacy, Banasthali University
Автор, ответственный за переписку.
Email: rajanichauhan.pharma@yahoo.com
Индия, Tonk, Rajasthan, 304022
A. Siddiqi
Department of Pharmacy, Jamia Hamdard University
Email: rajanichauhan.pharma@yahoo.com
Индия, New Delhi
J. Dwivedi
Department of Chemistry, Banasthali University
Email: rajanichauhan.pharma@yahoo.com
Индия, Tonk, Rajasthan, 304022