Synthesis of and HIV-1 Integrase Inhibition by 2-[7-(Fluorobenzyloxy)-4-Oxo-4hchromen-3-Yl]-1-Hydroxyimidazoles
- Авторлар: Nikitina P.1, Tkach I.1, Knyazhanskaya E.2, Gottikh M.2, Perevalov V.1
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Мекемелер:
- D. I. Mendeleev University of Chemical Technology of Russia
- Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
- Шығарылым: Том 50, № 8 (2016)
- Беттер: 513-518
- Бөлім: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244426
- DOI: https://doi.org/10.1007/s11094-016-1479-x
- ID: 244426
Дәйексөз келтіру
Аннотация
A series of six new 2-[7-(fluorobenzyloxy)-4-oxo-4H-chromen-3-yl]-1-hydroxyimidazoles were synthesized and characterized as potential HIV-1 integrase inhibitors. Prototropic tautomerism of the obtained 1-hydroxyimidazoles was discussed. Their ability to inhibit integrase catalytic activity in 3′-terminal processing and chain transfer reactions was studied. It was shown that these compounds did not exhibit noticeable inhibition.
Негізгі сөздер
Авторлар туралы
P. Nikitina
D. I. Mendeleev University of Chemical Technology of Russia
Хат алмасуға жауапты Автор.
Email: polinandrevna@yandex.ru
Ресей, 9 Miusskaya Sq, Moscow, 125047
I. Tkach
D. I. Mendeleev University of Chemical Technology of Russia
Email: polinandrevna@yandex.ru
Ресей, 9 Miusskaya Sq, Moscow, 125047
E. Knyazhanskaya
Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
Email: polinandrevna@yandex.ru
Ресей, Moscow, 119991
M. Gottikh
Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
Email: polinandrevna@yandex.ru
Ресей, Moscow, 119991
V. Perevalov
D. I. Mendeleev University of Chemical Technology of Russia
Email: polinandrevna@yandex.ru
Ресей, 9 Miusskaya Sq, Moscow, 125047