Synthesis of and HIV-1 Integrase Inhibition by 2-[7-(Fluorobenzyloxy)-4-Oxo-4hchromen-3-Yl]-1-Hydroxyimidazoles
- Authors: Nikitina P.A.1, Tkach I.I.1, Knyazhanskaya E.S.2, Gottikh M.B.2, Perevalov V.P.1
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Affiliations:
- D. I. Mendeleev University of Chemical Technology of Russia
- Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
- Issue: Vol 50, No 8 (2016)
- Pages: 513-518
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244426
- DOI: https://doi.org/10.1007/s11094-016-1479-x
- ID: 244426
Cite item
Abstract
A series of six new 2-[7-(fluorobenzyloxy)-4-oxo-4H-chromen-3-yl]-1-hydroxyimidazoles were synthesized and characterized as potential HIV-1 integrase inhibitors. Prototropic tautomerism of the obtained 1-hydroxyimidazoles was discussed. Their ability to inhibit integrase catalytic activity in 3′-terminal processing and chain transfer reactions was studied. It was shown that these compounds did not exhibit noticeable inhibition.
Keywords
About the authors
P. A. Nikitina
D. I. Mendeleev University of Chemical Technology of Russia
Author for correspondence.
Email: polinandrevna@yandex.ru
Russian Federation, 9 Miusskaya Sq, Moscow, 125047
I. I. Tkach
D. I. Mendeleev University of Chemical Technology of Russia
Email: polinandrevna@yandex.ru
Russian Federation, 9 Miusskaya Sq, Moscow, 125047
E. S. Knyazhanskaya
Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
Email: polinandrevna@yandex.ru
Russian Federation, Moscow, 119991
M. B. Gottikh
Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
Email: polinandrevna@yandex.ru
Russian Federation, Moscow, 119991
V. P. Perevalov
D. I. Mendeleev University of Chemical Technology of Russia
Email: polinandrevna@yandex.ru
Russian Federation, 9 Miusskaya Sq, Moscow, 125047