Email this article Synthesis of and HIV-1 Integrase Inhibition by 2-[7-(Fluorobenzyloxy)-4-Oxo-4hchromen-3-Yl]-1-Hydroxyimidazoles
- Authors: Nikitina P.A.1, Tkach I.I.1, Knyazhanskaya E.S.2, Gottikh M.B.2, Perevalov V.P.1
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Affiliations:
- D. I. Mendeleev University of Chemical Technology of Russia
- Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
- Issue: Vol 50, No 8 (2016)
- Pages: 513-518
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244426
- DOI: https://doi.org/10.1007/s11094-016-1479-x
- ID: 244426
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Abstract
A series of six new 2-[7-(fluorobenzyloxy)-4-oxo-4H-chromen-3-yl]-1-hydroxyimidazoles were synthesized and characterized as potential HIV-1 integrase inhibitors. Prototropic tautomerism of the obtained 1-hydroxyimidazoles was discussed. Their ability to inhibit integrase catalytic activity in 3′-terminal processing and chain transfer reactions was studied. It was shown that these compounds did not exhibit noticeable inhibition.
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About the authors
P. A. Nikitina
D. I. Mendeleev University of Chemical Technology of Russia
Author for correspondence.
Email: polinandrevna@yandex.ru
Russian Federation, 9 Miusskaya Sq, Moscow, 125047
I. I. Tkach
D. I. Mendeleev University of Chemical Technology of Russia
Email: polinandrevna@yandex.ru
Russian Federation, 9 Miusskaya Sq, Moscow, 125047
E. S. Knyazhanskaya
Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
Email: polinandrevna@yandex.ru
Russian Federation, Moscow, 119991
M. B. Gottikh
Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
Email: polinandrevna@yandex.ru
Russian Federation, Moscow, 119991
V. P. Perevalov
D. I. Mendeleev University of Chemical Technology of Russia
Email: polinandrevna@yandex.ru
Russian Federation, 9 Miusskaya Sq, Moscow, 125047
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