Synthesis and Cardiotropic Activity of Cyclic Methoxyphenyltriazaalkanes

Abstract

A new group of compounds – 1-(methoxybenzyl)-4-[2-((methoxybenzyl)amino)ethyl]piperazin-2,3-diones was synthesized. As compared with previously studied linear methoxyphenyltriazaalkanes, the structure of the triazaalkane linker was found to influence the cardiotropic actions of the corresponding compounds. The most effective among the new group was 1-(2,4-dimethoxybenzyl)-4{2-[2,4-dimethoxybenzyl)amino]ethyl}piperazin-2,3-dione, which had significant antiarrhythmic activity at a dose of 2 mg/kg in a calcium chloride arrhythmia model, along with activity at the level of a tendency in models of aconitin arrythmia and reperfusion ventricular fibrillation.