Synthesis and Cytotoxic Activity of Hydroxy-Substituted Glaucocalyxin A
- Authors: Xiang Z.1,2, Wu X.3, Zheng X.2
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Affiliations:
- College of Environment and Resources, Chongqing Technology and Business University
- Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing Technology and Business University
- Academic Quality Inspection and Evaluation Office, Chongqing Technology and Business University
- Issue: Vol 53, No 6 (2019)
- Pages: 535-538
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245850
- DOI: https://doi.org/10.1007/s11094-019-02033-9
- ID: 245850
Cite item
Abstract
Six new glaucocalyxin A derivatives were synthesized by hydroxy substitution, their structures were elucidated on the basis of spectral analysis, and cytotoxic activity was tested by MTT method. Not all of the obtained glaucocalyxin A derivatives have their cytotoxicity enhanced as a result of this substitution. Moreover, the hydroxy substitution did not increase the cytotoxicity of glaucocalyxin A significantly. Other glaucocalyxin A derivatives should be obtained by skeleton modification to find compounds with significant cytotoxicity for research and development of new antitumor drugs.
About the authors
Zhaobao Xiang
College of Environment and Resources, Chongqing Technology and Business University; Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing Technology and Business University
Author for correspondence.
Email: xiangzb@126.com
China, Chongqing, 400067; Chongqing, 400067
Xiaoling Wu
Academic Quality Inspection and Evaluation Office, Chongqing Technology and Business University
Email: xiangzb@126.com
China, Chongqing, 400067
Xuxu Zheng
Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing Technology and Business University
Email: xiangzb@126.com
China, Chongqing, 400067