Synthesis and Cytotoxic Activity of Hydroxy-Substituted Glaucocalyxin A
- 作者: Xiang Z.1,2, Wu X.3, Zheng X.2
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隶属关系:
- College of Environment and Resources, Chongqing Technology and Business University
- Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing Technology and Business University
- Academic Quality Inspection and Evaluation Office, Chongqing Technology and Business University
- 期: 卷 53, 编号 6 (2019)
- 页面: 535-538
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245850
- DOI: https://doi.org/10.1007/s11094-019-02033-9
- ID: 245850
如何引用文章
详细
Six new glaucocalyxin A derivatives were synthesized by hydroxy substitution, their structures were elucidated on the basis of spectral analysis, and cytotoxic activity was tested by MTT method. Not all of the obtained glaucocalyxin A derivatives have their cytotoxicity enhanced as a result of this substitution. Moreover, the hydroxy substitution did not increase the cytotoxicity of glaucocalyxin A significantly. Other glaucocalyxin A derivatives should be obtained by skeleton modification to find compounds with significant cytotoxicity for research and development of new antitumor drugs.
作者简介
Zhaobao Xiang
College of Environment and Resources, Chongqing Technology and Business University; Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing Technology and Business University
编辑信件的主要联系方式.
Email: xiangzb@126.com
中国, Chongqing, 400067; Chongqing, 400067
Xiaoling Wu
Academic Quality Inspection and Evaluation Office, Chongqing Technology and Business University
Email: xiangzb@126.com
中国, Chongqing, 400067
Xuxu Zheng
Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing Technology and Business University
Email: xiangzb@126.com
中国, Chongqing, 400067