Synthesis and Cytotoxic Activity of Hydroxy-Substituted Glaucocalyxin A
- Авторы: Xiang Z.1,2, Wu X.3, Zheng X.2
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Учреждения:
- College of Environment and Resources, Chongqing Technology and Business University
- Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing Technology and Business University
- Academic Quality Inspection and Evaluation Office, Chongqing Technology and Business University
- Выпуск: Том 53, № 6 (2019)
- Страницы: 535-538
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245850
- DOI: https://doi.org/10.1007/s11094-019-02033-9
- ID: 245850
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Аннотация
Six new glaucocalyxin A derivatives were synthesized by hydroxy substitution, their structures were elucidated on the basis of spectral analysis, and cytotoxic activity was tested by MTT method. Not all of the obtained glaucocalyxin A derivatives have their cytotoxicity enhanced as a result of this substitution. Moreover, the hydroxy substitution did not increase the cytotoxicity of glaucocalyxin A significantly. Other glaucocalyxin A derivatives should be obtained by skeleton modification to find compounds with significant cytotoxicity for research and development of new antitumor drugs.
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Об авторах
Zhaobao Xiang
College of Environment and Resources, Chongqing Technology and Business University; Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing Technology and Business University
Автор, ответственный за переписку.
Email: xiangzb@126.com
Китай, Chongqing, 400067; Chongqing, 400067
Xiaoling Wu
Academic Quality Inspection and Evaluation Office, Chongqing Technology and Business University
Email: xiangzb@126.com
Китай, Chongqing, 400067
Xuxu Zheng
Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing Technology and Business University
Email: xiangzb@126.com
Китай, Chongqing, 400067