Email this article Binding Constants of Maackia Amurensis Whole Extract and its Separate Flavanoids to Estradiol Receptors
- Authors: Kareva E.N.1,2, Tikhonov D.A.2, Mironov S.E.2, Fedoreev S.A.3, Kulesh N.I.3, Shimanovskii N.L.1
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Affiliations:
- N. I. Pirogov Russian National Research Medical University
- I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
- G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
- Issue: Vol 52, No 10 (2019)
- Pages: 855-859
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245507
- DOI: https://doi.org/10.1007/s11094-019-1914-x
- ID: 245507
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Abstract
Extract of Maackia amurensis containing genistein and resveratrol demonstrated competitive specific binding to estradiol receptors with more affinity for ERβ (average RBA = 6.25%) than for ERα (average RBA = 0.67%) in tests with experimental animals and clinical materials (endometrium biopsy). Associated flavonoids in the extract bound insignificantly to ERs although they could have a potentiating effect in the whole extract. Therefore, M. amurensis extract contained various phytoestrogens that determined the therapeutic potential (effect on cell growth, inflammation, apoptosis, angiogenesis, carbohydrate and lipid metabolism).
About the authors
E. N. Kareva
N. I. Pirogov Russian National Research Medical University; I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
Email: chem@folium.ru
Russian Federation, Ministry of Health of the RF, 1 Ostrovityanova St., Moscow, 117997; 8/2 Trubetskaya St., Moscow, 119991
D. A. Tikhonov
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
Email: chem@folium.ru
Russian Federation, 8/2 Trubetskaya St., Moscow, 119991
S. E. Mironov
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
Email: chem@folium.ru
Russian Federation, 8/2 Trubetskaya St., Moscow, 119991
S. A. Fedoreev
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 159 Prosp. 100 Let Vladivostoku, Vladivostok, 690022
N. I. Kulesh
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 159 Prosp. 100 Let Vladivostoku, Vladivostok, 690022
N. L. Shimanovskii
N. I. Pirogov Russian National Research Medical University
Email: chem@folium.ru
Russian Federation, Ministry of Health of the RF, 1 Ostrovityanova St., Moscow, 117997
