Enviar artigo por via de e-mail Binding Constants of Maackia Amurensis Whole Extract and its Separate Flavanoids to Estradiol Receptors
- Autores: Kareva E.1,2, Tikhonov D.2, Mironov S.2, Fedoreev S.3, Kulesh N.3, Shimanovskii N.1
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Afiliações:
- N. I. Pirogov Russian National Research Medical University
- I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
- G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
- Edição: Volume 52, Nº 10 (2019)
- Páginas: 855-859
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245507
- DOI: https://doi.org/10.1007/s11094-019-1914-x
- ID: 245507
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Resumo
Extract of Maackia amurensis containing genistein and resveratrol demonstrated competitive specific binding to estradiol receptors with more affinity for ERβ (average RBA = 6.25%) than for ERα (average RBA = 0.67%) in tests with experimental animals and clinical materials (endometrium biopsy). Associated flavonoids in the extract bound insignificantly to ERs although they could have a potentiating effect in the whole extract. Therefore, M. amurensis extract contained various phytoestrogens that determined the therapeutic potential (effect on cell growth, inflammation, apoptosis, angiogenesis, carbohydrate and lipid metabolism).
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Sobre autores
E. Kareva
N. I. Pirogov Russian National Research Medical University; I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
Email: chem@folium.ru
Rússia, Ministry of Health of the RF, 1 Ostrovityanova St., Moscow, 117997; 8/2 Trubetskaya St., Moscow, 119991
D. Tikhonov
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
Email: chem@folium.ru
Rússia, 8/2 Trubetskaya St., Moscow, 119991
S. Mironov
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
Email: chem@folium.ru
Rússia, 8/2 Trubetskaya St., Moscow, 119991
S. Fedoreev
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
Email: chem@folium.ru
Rússia, 159 Prosp. 100 Let Vladivostoku, Vladivostok, 690022
N. Kulesh
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
Email: chem@folium.ru
Rússia, 159 Prosp. 100 Let Vladivostoku, Vladivostok, 690022
N. Shimanovskii
N. I. Pirogov Russian National Research Medical University
Email: chem@folium.ru
Rússia, Ministry of Health of the RF, 1 Ostrovityanova St., Moscow, 117997
