电邮这篇文章 Binding Constants of Maackia Amurensis Whole Extract and its Separate Flavanoids to Estradiol Receptors
- 作者: Kareva E.N.1,2, Tikhonov D.A.2, Mironov S.E.2, Fedoreev S.A.3, Kulesh N.I.3, Shimanovskii N.L.1
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隶属关系:
- N. I. Pirogov Russian National Research Medical University
- I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
- G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
- 期: 卷 52, 编号 10 (2019)
- 页面: 855-859
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245507
- DOI: https://doi.org/10.1007/s11094-019-1914-x
- ID: 245507
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详细
Extract of Maackia amurensis containing genistein and resveratrol demonstrated competitive specific binding to estradiol receptors with more affinity for ERβ (average RBA = 6.25%) than for ERα (average RBA = 0.67%) in tests with experimental animals and clinical materials (endometrium biopsy). Associated flavonoids in the extract bound insignificantly to ERs although they could have a potentiating effect in the whole extract. Therefore, M. amurensis extract contained various phytoestrogens that determined the therapeutic potential (effect on cell growth, inflammation, apoptosis, angiogenesis, carbohydrate and lipid metabolism).
作者简介
E. Kareva
N. I. Pirogov Russian National Research Medical University; I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
Email: chem@folium.ru
俄罗斯联邦, Ministry of Health of the RF, 1 Ostrovityanova St., Moscow, 117997; 8/2 Trubetskaya St., Moscow, 119991
D. Tikhonov
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
Email: chem@folium.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991
S. Mironov
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF
Email: chem@folium.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991
S. Fedoreev
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
Email: chem@folium.ru
俄罗斯联邦, 159 Prosp. 100 Let Vladivostoku, Vladivostok, 690022
N. Kulesh
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
Email: chem@folium.ru
俄罗斯联邦, 159 Prosp. 100 Let Vladivostoku, Vladivostok, 690022
N. Shimanovskii
N. I. Pirogov Russian National Research Medical University
Email: chem@folium.ru
俄罗斯联邦, Ministry of Health of the RF, 1 Ostrovityanova St., Moscow, 117997
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