Email this article Immobilization of Benzocaine in Polymeric Nanocontainers. Pharmacokinetic Modeling
- Authors: Shkurenko G.Y.1, Lyrshchikov S.Y.1, Gorlov A.A.1, Al’tshuler O.G.1,2, Al’tshuler G.N.1
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Affiliations:
- Institute of Coal Chemistry and Materials Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences
- Kemerovo State University
- Issue: Vol 52, No 5 (2018)
- Pages: 464-466
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/245249
- DOI: https://doi.org/10.1007/s11094-018-1840-3
- ID: 245249
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Abstract
The possibility of immobilizing benzocaine in polymeric nanocontainers made of sulfonated cation exchangers, i.e., sulfonated polycalixarene and KU-23 30/100, was studied. The desorption kinetics of neutral and cationic benzocaine from the polymeric nanocontainers provided the desired drug-release pharmacokinetics upon peroral administration.
About the authors
G. Yu. Shkurenko
Institute of Coal Chemistry and Materials Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences
Email: altshulerh@gmail.com
Russian Federation, 18 Prosp. Sovetskii, Kemerovo, 650000
S. Yu. Lyrshchikov
Institute of Coal Chemistry and Materials Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences
Email: altshulerh@gmail.com
Russian Federation, 18 Prosp. Sovetskii, Kemerovo, 650000
A. A. Gorlov
Institute of Coal Chemistry and Materials Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences
Email: altshulerh@gmail.com
Russian Federation, 18 Prosp. Sovetskii, Kemerovo, 650000
O. G. Al’tshuler
Institute of Coal Chemistry and Materials Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences; Kemerovo State University
Author for correspondence.
Email: altshulerh@gmail.com
Russian Federation, 18 Prosp. Sovetskii, Kemerovo, 650000; 6 Krasnaya St., Kemerovo, 650043
G. N. Al’tshuler
Institute of Coal Chemistry and Materials Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences
Email: altshulerh@gmail.com
Russian Federation, 18 Prosp. Sovetskii, Kemerovo, 650000
