Effects of Pharmaceutical Preparations on the Rate of Degradation of Poly(Lactide-Co-Glycolide) Scaffolds
- Authors: Antonov E.N.1, Dunaev A.G.1, Minaeva S.A.1, Krotova L.I.1, Popov V.K.1
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Affiliations:
- Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
- Issue: Vol 52, No 1 (2018)
- Pages: 69-76
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/244994
- DOI: https://doi.org/10.1007/s11094-018-1767-8
- ID: 244994
Cite item
Abstract
The effects of acetylsalicylic acid, ibuprofen, 6-methyluracil, and chondroitin sulfate impregnated in poly-(lactide-co-glycolide) scaffolds of different chemical compositions and molecular weights using supercritical carbon dioxide on the processes of scaffold degradation in phosphate-buffered saline pH 7.4 were studied and the rate constants of these processes were determined. Incorporation of acetylsalicylic acid and ibuprofen into poly(lactide-co-glycolide) scaffolds was found to produce significant increases in the rate of hydrolysis of the polymer base, while the presence of methyluracil and chondroitin sulfate had virtually no effect.
About the authors
E. N. Antonov
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Author for correspondence.
Email: e_n_antonov@mail.ru
Russian Federation, 2 Pionerskaya Street, Troitsk, Moscow, 142190
A. G. Dunaev
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
Russian Federation, 2 Pionerskaya Street, Troitsk, Moscow, 142190
S. A. Minaeva
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
Russian Federation, 2 Pionerskaya Street, Troitsk, Moscow, 142190
L. I. Krotova
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
Russian Federation, 2 Pionerskaya Street, Troitsk, Moscow, 142190
V. K. Popov
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
Russian Federation, 2 Pionerskaya Street, Troitsk, Moscow, 142190