Effects of Pharmaceutical Preparations on the Rate of Degradation of Poly(Lactide-Co-Glycolide) Scaffolds
- 作者: Antonov E.1, Dunaev A.1, Minaeva S.1, Krotova L.1, Popov V.1
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隶属关系:
- Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
- 期: 卷 52, 编号 1 (2018)
- 页面: 69-76
- 栏目: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/244994
- DOI: https://doi.org/10.1007/s11094-018-1767-8
- ID: 244994
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详细
The effects of acetylsalicylic acid, ibuprofen, 6-methyluracil, and chondroitin sulfate impregnated in poly-(lactide-co-glycolide) scaffolds of different chemical compositions and molecular weights using supercritical carbon dioxide on the processes of scaffold degradation in phosphate-buffered saline pH 7.4 were studied and the rate constants of these processes were determined. Incorporation of acetylsalicylic acid and ibuprofen into poly(lactide-co-glycolide) scaffolds was found to produce significant increases in the rate of hydrolysis of the polymer base, while the presence of methyluracil and chondroitin sulfate had virtually no effect.
作者简介
E. Antonov
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: e_n_antonov@mail.ru
俄罗斯联邦, 2 Pionerskaya Street, Troitsk, Moscow, 142190
A. Dunaev
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
俄罗斯联邦, 2 Pionerskaya Street, Troitsk, Moscow, 142190
S. Minaeva
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
俄罗斯联邦, 2 Pionerskaya Street, Troitsk, Moscow, 142190
L. Krotova
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
俄罗斯联邦, 2 Pionerskaya Street, Troitsk, Moscow, 142190
V. Popov
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
俄罗斯联邦, 2 Pionerskaya Street, Troitsk, Moscow, 142190