Effects of Pharmaceutical Preparations on the Rate of Degradation of Poly(Lactide-Co-Glycolide) Scaffolds
- Autores: Antonov E.1, Dunaev A.1, Minaeva S.1, Krotova L.1, Popov V.1
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Afiliações:
- Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
- Edição: Volume 52, Nº 1 (2018)
- Páginas: 69-76
- Seção: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/244994
- DOI: https://doi.org/10.1007/s11094-018-1767-8
- ID: 244994
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Resumo
The effects of acetylsalicylic acid, ibuprofen, 6-methyluracil, and chondroitin sulfate impregnated in poly-(lactide-co-glycolide) scaffolds of different chemical compositions and molecular weights using supercritical carbon dioxide on the processes of scaffold degradation in phosphate-buffered saline pH 7.4 were studied and the rate constants of these processes were determined. Incorporation of acetylsalicylic acid and ibuprofen into poly(lactide-co-glycolide) scaffolds was found to produce significant increases in the rate of hydrolysis of the polymer base, while the presence of methyluracil and chondroitin sulfate had virtually no effect.
Sobre autores
E. Antonov
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Autor responsável pela correspondência
Email: e_n_antonov@mail.ru
Rússia, 2 Pionerskaya Street, Troitsk, Moscow, 142190
A. Dunaev
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
Rússia, 2 Pionerskaya Street, Troitsk, Moscow, 142190
S. Minaeva
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
Rússia, 2 Pionerskaya Street, Troitsk, Moscow, 142190
L. Krotova
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
Rússia, 2 Pionerskaya Street, Troitsk, Moscow, 142190
V. Popov
Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center, Russian Academy of Sciences
Email: e_n_antonov@mail.ru
Rússia, 2 Pionerskaya Street, Troitsk, Moscow, 142190