Seasonal Oscillations in Statistical Mean Measures of Blood Composition and Blood Cell Morphology in Healthy White Rats
- Authors: Pushkin A.S.1, Drugova E.D.1, Kamshilin S.A.1, Obraztsov N.V.1, Polekhina O.V.1, Dvoretskaya S.I.1, Churyumova A.I.1
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Affiliations:
- State Science Research Institute of Organic Chemistry and Technology
- Issue: Vol 51, No 9 (2017)
- Pages: 777-782
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244799
- DOI: https://doi.org/10.1007/s11094-017-1692-2
- ID: 244799
Cite item
Abstract
The aim of the present work was to identify seasonal oscillations in the composition and morphology of the blood in intact rats. Morphometric measures of blood were determined in 36 clinically healthy adult male rats in different seasons (spring, summer, and autumn) using the Mekos programmable system. Seasonal oscillations within established reference ranges were found and these need to be considered when performing preclinical studies of medicines in relation to their efficacy and safety.
Keywords
About the authors
A. S. Pushkin
State Science Research Institute of Organic Chemistry and Technology
Author for correspondence.
Email: dir@gosniiokht.ru
Russian Federation, Moscow
E. D. Drugova
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, Moscow
S. A. Kamshilin
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, Moscow
N. V. Obraztsov
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, Moscow
O. V. Polekhina
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, Moscow
S. I. Dvoretskaya
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, Moscow
A. I. Churyumova
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, Moscow