Seasonal Oscillations in Statistical Mean Measures of Blood Composition and Blood Cell Morphology in Healthy White Rats
- Авторлар: Pushkin A.1, Drugova E.1, Kamshilin S.1, Obraztsov N.1, Polekhina O.1, Dvoretskaya S.1, Churyumova A.1
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Мекемелер:
- State Science Research Institute of Organic Chemistry and Technology
- Шығарылым: Том 51, № 9 (2017)
- Беттер: 777-782
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244799
- DOI: https://doi.org/10.1007/s11094-017-1692-2
- ID: 244799
Дәйексөз келтіру
Аннотация
The aim of the present work was to identify seasonal oscillations in the composition and morphology of the blood in intact rats. Morphometric measures of blood were determined in 36 clinically healthy adult male rats in different seasons (spring, summer, and autumn) using the Mekos programmable system. Seasonal oscillations within established reference ranges were found and these need to be considered when performing preclinical studies of medicines in relation to their efficacy and safety.
Негізгі сөздер
Авторлар туралы
A. Pushkin
State Science Research Institute of Organic Chemistry and Technology
Хат алмасуға жауапты Автор.
Email: dir@gosniiokht.ru
Ресей, Moscow
E. Drugova
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Ресей, Moscow
S. Kamshilin
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Ресей, Moscow
N. Obraztsov
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Ресей, Moscow
O. Polekhina
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Ресей, Moscow
S. Dvoretskaya
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Ресей, Moscow
A. Churyumova
State Science Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Ресей, Moscow