Synthesis and Antidiabetic Activity of Thiazolo[2,3-f]Purine Derivatives and Their Analogs
- Authors: Spasov A.A.1, Khaliullin F.A.2, Babkov D.A.1, Timirkhanova G.A.2, Kuznetsova V.A.1, Naumenko L.V.1, Muleeva D.R.1, Maika O.Y.1, Prokhorova T.Y.1, Sturova E.A.1
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Affiliations:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Bashkir State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 51, No 7 (2017)
- Pages: 533-539
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244696
- DOI: https://doi.org/10.1007/s11094-017-1649-5
- ID: 244696
Cite item
Abstract
Thiazolo[2, 3-f]purine derivatives and their analogs – dihydrothiazolo[2, 3-f]purine, 7-(thietan-3-yl)purine, and 8-(2-hydroxypropylthio)purine derivatives – were synthesized. The compounds synthesized here had no effects on protein glycation reactions using glucose; they gave weak inhibition of glycogen phosphorylase; they had no hemorheological activity. Substances with hypotensive activity greater than that of Dibazol were found. A number of substances had hypoglycemic effects greater than those of chlorpropamide and Adebit. Two compounds inhibited dipeptidylpeptidase-4, but were less active than reference agent vildagliptin.
Keywords
About the authors
A. A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Volgograd, 400131
F. A. Khaliullin
Bashkir State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Ufa, 450008
D. A. Babkov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Volgograd, 400131
G. A. Timirkhanova
Bashkir State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Ufa, 450008
V. A. Kuznetsova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Volgograd, 400131
L. V. Naumenko
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Volgograd, 400131
D. R. Muleeva
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Volgograd, 400131
O. Yu. Maika
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Volgograd, 400131
T. Yu. Prokhorova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Volgograd, 400131
E. A. Sturova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Volgograd, 400131