Synthesis and Antidiabetic Activity of Thiazolo[2,3-f]Purine Derivatives and Their Analogs
- Авторы: Spasov A.1, Khaliullin F.2, Babkov D.1, Timirkhanova G.2, Kuznetsova V.1, Naumenko L.1, Muleeva D.1, Maika O.1, Prokhorova T.1, Sturova E.1
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Учреждения:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Bashkir State Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 51, № 7 (2017)
- Страницы: 533-539
- Раздел: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244696
- DOI: https://doi.org/10.1007/s11094-017-1649-5
- ID: 244696
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Аннотация
Thiazolo[2, 3-f]purine derivatives and their analogs – dihydrothiazolo[2, 3-f]purine, 7-(thietan-3-yl)purine, and 8-(2-hydroxypropylthio)purine derivatives – were synthesized. The compounds synthesized here had no effects on protein glycation reactions using glucose; they gave weak inhibition of glycogen phosphorylase; they had no hemorheological activity. Substances with hypotensive activity greater than that of Dibazol were found. A number of substances had hypoglycemic effects greater than those of chlorpropamide and Adebit. Two compounds inhibited dipeptidylpeptidase-4, but were less active than reference agent vildagliptin.
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Об авторах
A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, Volgograd, 400131
F. Khaliullin
Bashkir State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, Ufa, 450008
D. Babkov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, Volgograd, 400131
G. Timirkhanova
Bashkir State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, Ufa, 450008
V. Kuznetsova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, Volgograd, 400131
L. Naumenko
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, Volgograd, 400131
D. Muleeva
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, Volgograd, 400131
O. Maika
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, Volgograd, 400131
T. Prokhorova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, Volgograd, 400131
E. Sturova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, Volgograd, 400131