Search for Bactericides Among Derivatives of Deoxyvasicinone, Mackinazolinone, and Thienopyrimidinones
- Authors: Ortikov I.S.1, Turdibaev Z.É.1, Islamova Z.I.1, Élmuradov B.Z.1, Abdurazakov A.S.1, Bektemirov A.M.2, Osipova S.O.2, Khushbaktova Z.A.1, Syrov V.N.1, Shakhidoyatov K.M.1
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Affiliations:
- S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
- Research Institute of Epidemiology, Microbiology, and Infectious Diseases, Ministry of Public Health of the Republic of Uzbekistan
- Issue: Vol 51, No 6 (2017)
- Pages: 456-464
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244652
- DOI: https://doi.org/10.1007/s11094-017-1633-0
- ID: 244652
Cite item
Abstract
Series of arylidene- and arylhydroxymethyl derivatives of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-one and 2,3,4,10-tetrahydro-1H-pyrido[2,1-b]quinazolin-10-one were synthesized. Schiff bases were synthesized from amine derivatives. Hydroxymethylidene derivatives and arylaminomethylidene-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-9-ones and -2,3,4,10-tetrahydro-1H-pyrido[2,1-b]quinazolin-10-ones were obtained. The antimicrobial activity of the synthesized compounds against S. aureus, E. coli, Bacillus cereus, Candida albicans, and Pseudomonas aeruginosa was studied. It was concluded that the search for bactericides in these series was promising.
About the authors
I. S. Ortikov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbekistan, Tashkent
Zh. É. Turdibaev
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbekistan, Tashkent
Zh. I. Islamova
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbekistan, Tashkent
B. Zh. Élmuradov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbekistan, Tashkent
A. Sh. Abdurazakov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbekistan, Tashkent
A. M. Bektemirov
Research Institute of Epidemiology, Microbiology, and Infectious Diseases, Ministry of Public Health of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbekistan, Tashkent
S. O. Osipova
Research Institute of Epidemiology, Microbiology, and Infectious Diseases, Ministry of Public Health of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbekistan, Tashkent
Z. A. Khushbaktova
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Author for correspondence.
Email: zainab@icps.org.uz
Uzbekistan, Tashkent
V. N. Syrov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbekistan, Tashkent
Kh. M. Shakhidoyatov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbekistan, Tashkent