Synthesis and Analgesic and Antibacterial Activity of 5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones
- Authors: Gein V.L.1, Bobrovskaya O.V.1, Seliverstov G.V.1, Makhmudov R.R.2, Novikova V.V.1
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Affiliations:
- Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
- Perm State National Research University
- Issue: Vol 51, No 3 (2017)
- Pages: 187-190
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244526
- DOI: https://doi.org/10.1007/s11094-017-1579-2
- ID: 244526
Cite item
Abstract
A three-component reaction of aroylpyruvic acid methyl ester with a mixture of an aromatic aldehyde and 4-aminobenzenesulfonylacetamide (sulfacetamide) was used to synthesize 5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones. The structures of these compounds were established by IR, NMR, and 1H spectroscopy, along with mass spectrometry. The analgesic and antibacterial activities of these compounds were studied.
About the authors
V. L. Gein
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Author for correspondence.
Email: geinvl48@mail.ru
Russian Federation, 2 Polevaya Street, Perm, 614900
O. V. Bobrovskaya
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: geinvl48@mail.ru
Russian Federation, 2 Polevaya Street, Perm, 614900
G. V. Seliverstov
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: geinvl48@mail.ru
Russian Federation, 2 Polevaya Street, Perm, 614900
R. R. Makhmudov
Perm State National Research University
Email: geinvl48@mail.ru
Russian Federation, Perm
V. V. Novikova
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: geinvl48@mail.ru
Russian Federation, 2 Polevaya Street, Perm, 614900