Synthesis and Analgesic and Antibacterial Activity of 5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones

V. L. Gein; O. V. Bobrovskaya; G. V. Seliverstov; R. R. Makhmudov; V. V. Novikova

doi:10.1007/s11094-017-1579-2

Synthesis and Analgesic and Antibacterial Activity of 5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones

作者: Gein V.¹, Bobrovskaya O.¹, Seliverstov G.¹, Makhmudov R.², Novikova V.¹
隶属关系:
1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
2. Perm State National Research University
期: 卷 51, 编号 3 (2017)
页面: 187-190
栏目: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244526
DOI: https://doi.org/10.1007/s11094-017-1579-2
ID: 244526

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A three-component reaction of aroylpyruvic acid methyl ester with a mixture of an aromatic aldehyde and 4-aminobenzenesulfonylacetamide (sulfacetamide) was used to synthesize 5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones. The structures of these compounds were established by IR, NMR, and ¹H spectroscopy, along with mass spectrometry. The analgesic and antibacterial activities of these compounds were studied.