Synthesis and Pharmacological Activity of Some α-Aminoketone Hydrochlorides

G. A. Gevorgyan; N. K. Gasparyan; O. A. Papoyan; D. A. Avakimyan; A. A. Tatevosyan; H. A. Panosyan

doi:10.1007/s11094-017-1565-8

Synthesis and Pharmacological Activity of Some α-Aminoketone Hydrochlorides

Authors: Gevorgyan G.A.¹, Gasparyan N.K.¹, Papoyan O.A.¹, Avakimyan D.A.¹, Tatevosyan A.A.¹, Panosyan H.A.²
Affiliations:
1. A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
2. Molecular Structure Research Center, National Academy of Sciences of Armenia
Issue: Vol 51, No 2 (2017)
Pages: 107-110
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244512
DOI: https://doi.org/10.1007/s11094-017-1565-8
ID: 244512

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Abstract

New α-bromoethanones were synthesized by bromination of 1-[4(3,4)-substituted phenyl]-2-phenyl[3(4)-substituted phenyl]ethanones and were reacted with various amines in Et₂O to produce the corresponding 1-[4-alkoxyphenyl(3-bromophenyl)]-2-phenyl-[3(4)-halophenyl]-2-aminoethanones. It was shown that the synthesized compounds possessed moderate antibacterial and pronounced peripheral n-cholinolytic activity.