Synthesis and Pharmacological Activity of Some α-Aminoketone Hydrochlorides

G. A. Gevorgyan; N. K. Gasparyan; O. A. Papoyan; D. A. Avakimyan; A. A. Tatevosyan; H. A. Panosyan

doi:10.1007/s11094-017-1565-8

Synthesis and Pharmacological Activity of Some α-Aminoketone Hydrochlorides

Авторлар: Gevorgyan G.¹, Gasparyan N.¹, Papoyan O.¹, Avakimyan D.¹, Tatevosyan A.¹, Panosyan H.²
Мекемелер:
1. A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
2. Molecular Structure Research Center, National Academy of Sciences of Armenia
Шығарылым: Том 51, № 2 (2017)
Беттер: 107-110
Бөлім: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244512
DOI: https://doi.org/10.1007/s11094-017-1565-8
ID: 244512

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Аннотация

New α-bromoethanones were synthesized by bromination of 1-[4(3,4)-substituted phenyl]-2-phenyl[3(4)-substituted phenyl]ethanones and were reacted with various amines in Et₂O to produce the corresponding 1-[4-alkoxyphenyl(3-bromophenyl)]-2-phenyl-[3(4)-halophenyl]-2-aminoethanones. It was shown that the synthesized compounds possessed moderate antibacterial and pronounced peripheral n-cholinolytic activity.

Негізгі сөздер

bromination, α-bromoethanones, α-aminoketones, antibacterial and peripheral n-cholinolytic activity

Авторлар туралы

G. Gevorgyan

A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia

Хат алмасуға жауапты Автор.
Email: gyulgev@gmail.com
Армения, 26 Prosp. Azatutyan, Yerevan, 0014

N. Gasparyan

A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia