Synthesis and Pharmacological Activity of Some α-Aminoketone Hydrochlorides

G. A. Gevorgyan; N. K. Gasparyan; O. A. Papoyan; D. A. Avakimyan; A. A. Tatevosyan; H. A. Panosyan

doi:10.1007/s11094-017-1565-8

Synthesis and Pharmacological Activity of Some α-Aminoketone Hydrochlorides

作者: Gevorgyan G.¹, Gasparyan N.¹, Papoyan O.¹, Avakimyan D.¹, Tatevosyan A.¹, Panosyan H.²
隶属关系:
1. A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
2. Molecular Structure Research Center, National Academy of Sciences of Armenia
期: 卷 51, 编号 2 (2017)
页面: 107-110
栏目: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244512
DOI: https://doi.org/10.1007/s11094-017-1565-8
ID: 244512

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详细

New α-bromoethanones were synthesized by bromination of 1-[4(3,4)-substituted phenyl]-2-phenyl[3(4)-substituted phenyl]ethanones and were reacted with various amines in Et₂O to produce the corresponding 1-[4-alkoxyphenyl(3-bromophenyl)]-2-phenyl-[3(4)-halophenyl]-2-aminoethanones. It was shown that the synthesized compounds possessed moderate antibacterial and pronounced peripheral n-cholinolytic activity.

关键词

bromination, α-bromoethanones, α-aminoketones, antibacterial and peripheral n-cholinolytic activity

作者简介

G. Gevorgyan

A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia

编辑信件的主要联系方式.
Email: gyulgev@gmail.com
亚美尼亚, 26 Prosp. Azatutyan, Yerevan, 0014

N. Gasparyan

A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia