Email this article Synthesis and Analgesic Activity of 9-Aryl-12-Imino-10,11-Dioxatricyclo[5.3.2.01,6]Dodecane-7,8,8-Tricarbonitriles and 3-Aryl-1,1,2,2-Tetracyanocyclopropanes
- Authors: Mar’yasov M.A.1, Sheverdov V.P.1, Nasakin O.E.1, Makhmudov R.R.2
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Affiliations:
- I. N. Ul’yanov Chuvash State University
- Perm State University
- Issue: Vol 50, No 9 (2016)
- Pages: 580-582
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244441
- DOI: https://doi.org/10.1007/s11094-016-1494-y
- ID: 244441
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Abstract
9-Aryl-12-imino-10,11-dioxatricyclo[5.3.2.01,6]dodecane-7,8,8-tricarbonitriles were synthesized via the reaction of 1-(2-oxocyclohexyl)ethane-1,1,2,2-tetracarbonitrile with aromatic aldehydes. The corresponding 3-aryl-1,1,2,2-tetracyanocyclopropanes were prepared from bromomalononitrile and aromatic aldehydes. The structures of the synthesized compounds were elucidated using IR, PMR, 13C NMR, and mass spectra. The analgesic activity of the synthesized compounds was investigated.
About the authors
M. A. Mar’yasov
I. N. Ul’yanov Chuvash State University
Author for correspondence.
Email: marsikprovisor@mail.ru
Russian Federation, Cheboksary, Chuvash Republic, 428010
V. P. Sheverdov
I. N. Ul’yanov Chuvash State University
Email: marsikprovisor@mail.ru
Russian Federation, Cheboksary, Chuvash Republic, 428010
O. E. Nasakin
I. N. Ul’yanov Chuvash State University
Email: marsikprovisor@mail.ru
Russian Federation, Cheboksary, Chuvash Republic, 428010
R. R. Makhmudov
Perm State University
Email: marsikprovisor@mail.ru
Russian Federation, Perm, 614990
