Synthesis and Analgesic Activity of 9-Aryl-12-Imino-10,11-Dioxatricyclo[5.3.2.01,6]Dodecane-7,8,8-Tricarbonitriles and 3-Aryl-1,1,2,2-Tetracyanocyclopropanes

Abstract

9-Aryl-12-imino-10,11-dioxatricyclo[5.3.2.0^1,6]dodecane-7,8,8-tricarbonitriles were synthesized via the reaction of 1-(2-oxocyclohexyl)ethane-1,1,2,2-tetracarbonitrile with aromatic aldehydes. The corresponding 3-aryl-1,1,2,2-tetracyanocyclopropanes were prepared from bromomalononitrile and aromatic aldehydes. The structures of the synthesized compounds were elucidated using IR, PMR, ¹³C NMR, and mass spectra. The analgesic activity of the synthesized compounds was investigated.