Fibrin- and Fibrinogenolytic Effect of Extracellular Proteinases of Microfungi  Aspergillus alliaceus  7dN1 and  A. terreus  2

A. A. Osmolovskiy; Осмоловский А. А.; S. D. Klyagin; Клягин С. Д.; T. V. Vashkevich; Вашкевич Т. В.; A. V. Kurakov; Кураков А. В.; V. G. Kreyer; Крейер В. Г.

doi:10.31857/S0026364823040086

Fibrin- and Fibrinogenolytic Effect of Extracellular Proteinases of Microfungi Aspergillus alliaceus 7dN1 and A. terreus 2

作者: Osmolovskiy A.¹^,2, Klyagin S.¹, Vashkevich T.¹, Kurakov A.¹, Kreyer V.¹
隶属关系:
1. Faculty of Biology of M.V. Lomonosov Moscow State University
2. Faculty of Biotechnology of M.V. Lomonosov Moscow State University
期: 卷 57, 编号 4 (2023)
页面: 298-300
栏目: SHORT COMMUNICATIONS
URL: https://journals.rcsi.science/0026-3648/article/view/138097
DOI: https://doi.org/10.31857/S0026364823040086
EDN: https://elibrary.ru/VVADYR
ID: 138097

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详细

Proteolytic cleavage of fibrin and fibrinogen under the action of proteases of microfungi Aspergillus alliaceus 7dN1 and A. terreus 2 was carried out. It was shown that both enzymes can have strong α-fibrinogenase and moderate β-fibrinogenase activity, practically without affecting the γ-chains of these molecules. The products of cleavage in the time interval up to 60 min are polypeptides with a molecular weight of 15 kDa or less.

关键词

fibrinolytic enzymes, microfungi proteinases, thrombolysis

作者简介

A. Osmolovskiy

Faculty of Biology of M.V. Lomonosov Moscow State University; Faculty of Biotechnology of M.V. Lomonosov Moscow State University

编辑信件的主要联系方式.
Email: aosmol@mail.ru
Russia, Moscow; Russia, Moscow

S. Klyagin

Faculty of Biology of M.V. Lomonosov Moscow State University

编辑信件的主要联系方式.
Email: sergey_klyagin@mail.ru
Russia, Moscow

T. Vashkevich

Faculty of Biology of M.V. Lomonosov Moscow State University

编辑信件的主要联系方式.
Email: 12878853t@gmail.com
Russia, Moscow

A. Kurakov

Faculty of Biology of M.V. Lomonosov Moscow State University

编辑信件的主要联系方式.
Email: kurakov57@mail.ru
Russia, Moscow

V. Kreyer

Faculty of Biology of M.V. Lomonosov Moscow State University

编辑信件的主要联系方式.
Email: vkreyer@yandex.ru
Russia, Moscow

参考

Batomunkueva B.P., Egorov N.S. Preparations of extracellular proteinases from Aspergillus ochraceus 513 and Aspergillus alliaceus 7dN1. Mikrobiologiya. 2002. V. 71. № 1. P. 56–58.
Lal V. Fibrinolytic drug therapy in the management of intravascular thrombosis, especially acute myocardial infarction. A review. Asian J. Pharm. Clin. Res. 2017. V. 2. A. 555593. https://doi.org/10.19080/JPCR.2017.02.555593
Osmolovskiy A.A., Zvonareva E.S., Kreyer V.G. et al. Thrombolytic potential of the extracellular proteinase of micromycete Aspergillus terreus 2. Mikologiya i fitopatologiya. 2021. V. 55 (3). P. 225–228 (in Russ.). https://doi.org/10.31857/S0026364821030089
Osmolovskiy A.A., Zvonareva E.S., Kreyer V.G. et al. The effect of micromycete extracellular proteases of Aspergillus genus on the proteins of haemostatic system. Russ. J. Bioorg. Chem. 2014. V. 40 (6). P. 634–639.
Petraglia T., Latronico T., Liuzzi G.M. et al. Edible mushrooms as source of fibrin(ogen)olytic enzymes: Comparison between four cultivated species. Molecules. 2022. V. 27. A. 8145. https://doi.org/10.3390/molecules27238145
Zvonareva E.S., Osmolovskiy A.A., Kreier V.G. et al. Production of proteinase with plasmin-like and prekallikrein activating activity by the micromycete Aspergillus terreus. Appl. Biochem. Microbiol. 2018. V. 54 (2). P. 206–210. https://doi.org/10.1134/S0003683818020151
Осмоловский А.А., Звонарева Е.С., Крейер В.Г. и др. (Osmolovskiy et al.) Секреция протеиназ с фибринолитической активностью микромицетами рода Aspergillus // Вестник Моск. ун-та. Сер. 16. Биол. 2018. Т. 73 (1). С. 39–42.
Осмоловский А.А., Звонарева Е.С., Крейер В.Г. и др. (Osmolovskiy et al.) Тромболитический потенциал внеклеточной протеиназы микромицета Aspergillus terreus 2 // Микология и фитопатология. 2021. Т. 55. № 3. С. 225–228.