Fibrin- and Fibrinogenolytic Effect of Extracellular Proteinases of Microfungi  Aspergillus alliaceus  7dN1 and  A. terreus  2

A. A. Osmolovskiy; Осмоловский А. А.; S. D. Klyagin; Клягин С. Д.; T. V. Vashkevich; Вашкевич Т. В.; A. V. Kurakov; Кураков А. В.; V. G. Kreyer; Крейер В. Г.

doi:10.31857/S0026364823040086

Fibrin- and Fibrinogenolytic Effect of Extracellular Proteinases of Microfungi Aspergillus alliaceus 7dN1 and A. terreus 2

Авторлар: Osmolovskiy A.¹^,2, Klyagin S.¹, Vashkevich T.¹, Kurakov A.¹, Kreyer V.¹
Мекемелер:
1. Faculty of Biology of M.V. Lomonosov Moscow State University
2. Faculty of Biotechnology of M.V. Lomonosov Moscow State University
Шығарылым: Том 57, № 4 (2023)
Беттер: 298-300
Бөлім: КРАТКИЕ СООБЩЕНИЯ
URL: https://journals.rcsi.science/0026-3648/article/view/138097
DOI: https://doi.org/10.31857/S0026364823040086
EDN: https://elibrary.ru/VVADYR
ID: 138097

Дәйексөз келтіру

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Ашық рұқсат
Рұқсат жабық

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Рұқсат жабық

Тек жазылушылар үшін

Аннотация
Авторлар туралы
Әдебиет тізімі
Қосымша файлдар
Статистика

Аннотация

Proteolytic cleavage of fibrin and fibrinogen under the action of proteases of microfungi Aspergillus alliaceus 7dN1 and A. terreus 2 was carried out. It was shown that both enzymes can have strong α-fibrinogenase and moderate β-fibrinogenase activity, practically without affecting the γ-chains of these molecules. The products of cleavage in the time interval up to 60 min are polypeptides with a molecular weight of 15 kDa or less.

Негізгі сөздер

fibrinolytic enzymes, microfungi proteinases, thrombolysis

Авторлар туралы

A. Osmolovskiy

Faculty of Biology of M.V. Lomonosov Moscow State University; Faculty of Biotechnology of M.V. Lomonosov Moscow State University

Хат алмасуға жауапты Автор.
Email: aosmol@mail.ru
Russia, Moscow; Russia, Moscow

S. Klyagin

Faculty of Biology of M.V. Lomonosov Moscow State University

Хат алмасуға жауапты Автор.
Email: sergey_klyagin@mail.ru
Russia, Moscow

T. Vashkevich

Faculty of Biology of M.V. Lomonosov Moscow State University

Хат алмасуға жауапты Автор.
Email: 12878853t@gmail.com
Russia, Moscow

A. Kurakov

Faculty of Biology of M.V. Lomonosov Moscow State University

Хат алмасуға жауапты Автор.
Email: kurakov57@mail.ru
Russia, Moscow

V. Kreyer

Faculty of Biology of M.V. Lomonosov Moscow State University

Хат алмасуға жауапты Автор.
Email: vkreyer@yandex.ru
Russia, Moscow

Әдебиет тізімі

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Osmolovskiy A.A., Zvonareva E.S., Kreyer V.G. et al. Thrombolytic potential of the extracellular proteinase of micromycete Aspergillus terreus 2. Mikologiya i fitopatologiya. 2021. V. 55 (3). P. 225–228 (in Russ.). https://doi.org/10.31857/S0026364821030089
Osmolovskiy A.A., Zvonareva E.S., Kreyer V.G. et al. The effect of micromycete extracellular proteases of Aspergillus genus on the proteins of haemostatic system. Russ. J. Bioorg. Chem. 2014. V. 40 (6). P. 634–639.
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Zvonareva E.S., Osmolovskiy A.A., Kreier V.G. et al. Production of proteinase with plasmin-like and prekallikrein activating activity by the micromycete Aspergillus terreus. Appl. Biochem. Microbiol. 2018. V. 54 (2). P. 206–210. https://doi.org/10.1134/S0003683818020151
Осмоловский А.А., Звонарева Е.С., Крейер В.Г. и др. (Osmolovskiy et al.) Секреция протеиназ с фибринолитической активностью микромицетами рода Aspergillus // Вестник Моск. ун-та. Сер. 16. Биол. 2018. Т. 73 (1). С. 39–42.
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